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From I-90 - Mass Pike - (Boston, Albany) exit 10 to I-395 South. Take exit 2. At the ramp follow signs for Rt. 16 Webster (Main Street). Proceed through 2 sets of lights. Take the second left after the McDonalds, which is Whitcomb Street. Proceed up Whitcomb Street to St. Joseph Basilica, easily recognizable from its twin towers.
From I-95 (New York, Connecticut) follow signs for I-395 North and then follow the directions above.